Research Specialist Sen

Position Information

Position Information

Present Position Number 01093W
Role Code Title Laboratory & Research Spec II
Position Title Research Specialist Sen
Position Summary

The position starting in March 2017 is available through the Department of Applied Science at the College of William and Mary in Williamsburg, Virginia.
The position is part of a concerted experimental effort to develop and employ biophysical, biochemical, and biological methods to investigate the interplay of host defense mechanisms at biological membranes. The main tasks are to work with the PI to 1) identify physicochemical principles underlying molecular recognition and synergistic effects between biomolecules that converge at lipid membranes to exert their host-defense function; 2) develop quantitative tools to engineer biological macromolecules and systems with useful biological properties for innovative applications in treating infectious and inflammatory diseases and healing wounds. The work encompasses molecular design, synthesis, assembly, biophysical characterization of binding affinities and three-dimensional structures, and testing of biological efficacy. The specific molecules of interest are evolution-tested classes of membrane peptides, proteins, and lipids that act together on drug resistant bacteria, persister cells, biofilms, and tumors, and elicit immunomodulatory effects on host cells. Biophysical techniques such as solid-state NMR, oriented circular dichroism, isothermal titration calorimetry, and surface plasmon resonance will be employed to identify structural and physicochemical characteristics underlying function while biological assays will be used to quantify function, efficacy, stability, and cytotoxicity.
The position provides opportunities to interact with leading groups in the fields of solid-state NMR, neutron diffraction, molecular dynamics, chemical biology, biocatalysis, bacterial infections, G-protein coupled receptor activation of immune cells, and cancer imaging. The NMR facility at William and Mary houses two Bruker wide bore superconducting magnets operating at field strengths of 17.6 T and 7.05 T. An NMR specialist maintains and services the facility, and trains new users. The NMR laboratory is coupled with a biophysical and biological chemistry wet lab facility for sample preparation, housed in the new integrated science center. Additional instrumentation is available through core facilities at William and Mary and through collaborations with scientists at national laboratories and institutes.
We are looking for highly motivated, enthusiastic, inquisitive, creative, and outcome-oriented candidates who have the ability to interact collaboratively within a team and engage in interdisciplinary research. Duties will include assisting PI and her team in designing, modifying, and performing research experiments; collecting, analyzing, and interpreting data; operating and maintaining laboratory equipment and computers; interfacing effectively with internal and external parties to discuss research projects and provide assistance; perform literature searches related to projects and experimental procedures; writing manuscripts for publication; and supervising undergraduate and graduate students.

Required Qualifications

Candidates must hold a Ph.D. in chemistry, biophysics, or a related field, and must have strong experience in biophysical methods and experimental biomolecular NMR

Preferred Qualifications

Demonstrated expertise in recombinant expression of isotopically labeled peptides and proteins, and familiarity with NMR techniques for solving structures of biomolecules are expected. Strong verbal, oral, and written communication skills in English, organizational and project management skills, motivation to engage in interdisciplinary research, and ability to interact collaboratively within a team of people from culturally diverse backgrounds are also necessary

Advertised Pay Range Commensurate with Experience
Department Applied Science Dept - 3KE510
Location William & Mary
University Salary Range

U07
Job Open Date 02/10/2017
Review Begin Date 03/24/2017
Job Close Date
Open Until Filled Yes
Employment Category Operational FT
Position Term 12-Month
Special Application Instructions

Please list your references in the “other doc” field under Applicant Documents.

Conditions of Employment:

The initial contract will be for a duration of one year and will be renewable for a second year. The salary is commensurate with experience and will be based on the College of William and Mary guidelines.

This is a restricted position and continued employment is dependent on funding.

EEO Statement

The College of William & Mary values diversity and invites applications from underrepresented groups who will enrich the research, teaching and service missions of the university. The College is an Equal Opportunity/Affirmative Action employer and encourages applications from women, minorities, protected veterans, and individuals with disabilities.

Background Check Statement

The College of William & Mary is committed to providing a safe campus community. W&M conducts background investigations for applicants being considered for employment. Background investigations include reference checks, a criminal history record check, and when appropriate, a financial (credit) report or driving history check.

Supplemental Question

Required fields are indicated with an asterisk (*).

Supplemental Documents

Required Documents
  1. Resume/Curriculum Vitae
  2. Cover Letter
  3. Other Doc
  4. Other 2
  5. Other 3
  6. Other 4
  7. Candidate Statement
  8. Research Statement
  9. Writing Sample
Optional Documents